Multiple Myeloma Low Anion Gap

Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Multiple myeloma patients stratified by clinical stages had anion gap of 8 7 1 7 in stage i 7 93 0 47 in stage ii and 5 65 0 31 in stage iii. A low anion gap is relatively rare but may occur from the presence of abnormal positively charged proteins as in multiple myeloma.

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Multiple Myeloma Under A Microscope

The anion gap was evaluated in 26 consecutive patients with multiple myeloma 15 igg and 11 iga.

Multiple myeloma low anion gap. Within this small percentage over 90 percent of the results. The normal value for the serum anion gap is 8 16 meq l. It is not known however if testing a person s anion gap is a useful tool for. Hypoalbuminemia is also considered a contributing factor to having a low anion gap in people with multiple myeloma.

The average union gap was found reduced only in igg myeloma. The clinical value of this calculated parameter is the main focus of this article. A significant correlation was found in igg myeloma when anion gap was expressed as a function of the serum monoclonal protein concentration. A published review found that out of 67 000 calculations of anion gap a low anion gap was calculated less than 1 percent of the time.

The partialdifferences between our results and those of other authors are discussed. An anion gap test measures the chemical balance in your blood. Tests to diagnose metabolic acidosis include. The anion gap ag is a calculated parameter derived from measured serum plasma electrolyte concentrations.

Plasma cells help you fight infections by making antibodies that recognize and attack germs. It compares the numbers of positively and negatively charged particles including sodium. A low or negative anion gap could theoretically occur if additional cations other than sodium caused the retention of additional chloride and bicarbonate or both. Multiple myeloma causes cancer cells to accumulate in the bone marrow where they crowd out healthy blood cells.

What is the normal range for anion gap. Instead in the subjects with iga myeloma it resulted as increased. It has been postulated that the. Both increased and reduced anion gap have clinical significance but the deviation from normal that has most clinical significance is increased anion gap.