Calcium Levels Homeostasis

Calcium homeostasis serum calcium level is maintained at a constant level for the optimal excitability of neural and muscular tissue and the coordinated functioning of various organ systems in the human body. Calcium homeostasis also called calcium metabolism is the process by which our bodies maintain calcium levels within this optimal range. Obviously calcium homeostasis is critical.

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The human body uses calcium and phosphate in several ways notably to build bones.

Calcium levels homeostasis. Homeostasis is complex yet three important hormones are responsible for modulating most of the extracellular control of these minerals. Hypocalcemia can result in problems with blood coagulation muscle contraction nerve functioning and bone strength. Whereas the normal serum ionized calcium level varies from 1 15 to 1 29 mmol l the calcium concentration of dialysate in which all of the calcium is ionized usually ranges from 1 25 to 1 79 mmol l. Calcium homeostasis is also related to oral calcium intake vitamin d prescription parathyroid hormone levels and phosphate levels.

Vitamin d is converted to calcidiol also called calcifediol in the liver which is then converted to. The skeletal endocrine and digestive systems play a role in this but the kidneys do too. Calcium homeostasis i e maintaining a blood calcium level of about 10 mg dl is critical for normal body functions. Inadequate calcium levels can result in osteoporosis.

The signal for increased pth. Two primary hormones drive this process working together to regulate the absorption and release of calcium from our diets and from our bones. Parathyroid hormone acts directly on bone and kidney and indirectly on the intestine to maintain or restore the serum calcium level. Pth also signals the kidney to reclaim more calcium before it is excreted in the urine and also stimulates synthesis of the active form of vitamin d.

Calcium release from bone is regulated by parathyroid hormone. Homeostasis is the activity performed by many life forms to maintain stable internal conditions throughout the organism. Key points calcium homeostasis regulates calcium flow to and from the bones. If the serum calcium level falls the parathyroid glands release pth into the blood and this signals cells in bone osteoclasts to release calcium from the bone surfaces.

Hypercalcemia can result in lethargy sluggish reflexes constipation and loss of appetite confusion and coma. Calcium is also an important factor for neuron communication blood clotting and muscle contraction. These body systems work together to maintain a normal calcium level in the blood figure 5 24.